"Upstate Manhattan,"
Upper ManhattanThe northernmost area of "uptown" is Upper Manhattan, encompassing the neighborhoods of Washington Heights and Inwood, and often
Harlem*.
Midtown is sometimes broken into "Midtown East" and "Midtown West" Some areas, especially Times Square and Fifth Avenue, have massive clusters of retail establishments. Midtown is a neighborhood in Manhattan, New York City that has such world-famous commercial buildings as Rockefeller Center, Radio City Music Hall, and the Empire State Building.Restaurant Row
Within "downtown" is Lower Manhattan, a neighborhood defined as everything approximately south of Barclay Street and the Brooklyn Bridge; it is one of the best-known parts of the city, home to City Hall, Wall Street, the South Street Seaport, Manhattan's courthouses, the site of the former World Trade Center (often referred to commonly as "Ground Zero"), as well as a number of other significant landmarks.
Fifth Avenue roughly bisects Manhattan Island and acts as the demarcation line for latitudinal east/west designations (e.g., East 27th Street, West 42nd Street). South of Waverly Place in Manhattan, Fifth Avenue terminates and Broadway becomes the east/west demarcation line.
